Calf pseudohypertrophy is most commonly associated with which muscular condition?

Calf pseudohypertrophy is most commonly associated with Duchenne's muscular dystrophy, a genetic disorder characterized by progressive muscle degeneration and weakness. The condition results from mutations in the dystrophin gene, leading to the loss of structural integrity in muscle cells.

In Duchenne's muscular dystrophy, the calves often appear enlarged due to the replacement of healthy muscle tissue with fibrous and fatty tissues, resulting in pseudohypertrophy. This enlargement is not due to an increase in muscle fibers but rather an abnormal muscle repair response. As the disease progresses, affected individuals experience muscle weakness and loss of function, particularly in the proximal muscles. Calf pseudohypertrophy is one of the classic clinical findings and is often observed in young boys with this condition, typically becoming apparent between ages 2 and 5.

Other conditions listed, such as Becker's muscular dystrophy, spinal muscular atrophy, and myasthenia gravis, do not typically present with calf pseudohypertrophy. While Becker's muscular dystrophy is similar to Duchenne's and might exhibit some muscle enlargement, it usually presents with a milder phenotype and later onset. Spinal muscular atrophy involves the degeneration of motor neurons leading to muscle wasting but does not cause the same