Cases of macroglobulinemia typically present with which of the following symptoms?

Macroglobulinemia, often associated with conditions such as Waldenström's macroglobulinemia, is characterized by the presence of elevated levels of large immunoglobulin M (IgM) antibodies in the blood. This condition primarily leads to hyperviscosity syndrome due to the increased viscosity of the blood caused by the high levels of circulating IgM.

Fatigue is a common symptom experienced by patients with macroglobulinemia. This is often due to several factors, including anemia that can occur in these patients as well as the overall systemic effects of the disease. The increased blood viscosity can impair circulation and oxygen delivery to tissues, contributing to a sense of tiredness and decreased energy levels.

The other symptoms listed in the options do not typically present with macroglobulinemia. High fever may suggest an infectious process or inflammatory response, weight gain is not directly associated with macroglobulinemia, and severe embolic events are generally more related to conditions that significantly increase clotting or platelet activation, rather than being the hallmark of the hyperviscosity seen in macroglobulinemia. Understanding these associations can help in recognizing the clinical manifestations of this condition and the underlying pathophysiology.