Councilman bodies are associated with which of the following conditions?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Councilman bodies, also known as apoptotic bodies, are indicative of cell death and are commonly associated with liver conditions, particularly in the context of viral hepatitis. These bodies represent apoptotic hepatocytes that have undergone programmed cell death due to the damaging effects of viral infections.

In cases of toxic or viral hepatitis, such as those caused by hepatitis viruses, the virus invades hepatocytes leading to cellular injury and subsequent apoptosis. The presence of Councilman bodies can be observed histologically on liver biopsy, making them a hallmark of this liver injury process. This condition often presents with elevated liver enzymes, jaundice, and potential complications such as acute liver failure in severe cases.

On the other hand, alcoholic liver disease primarily leads to fatty changes and alcoholic hepatitis but is not characterized by the presence of Councilman bodies. Similarly, cervical cancer and Hodgkin's lymphoma are unrelated to liver pathology and do not feature these structures in their histopathological findings. Therefore, the strongest association of Councilman bodies lies with toxic or viral hepatitis, confirming the answer as correct.

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