Deficiency in which vitamin can result in lactic acidosis?

A deficiency in biotin, also known as vitamin B7, can lead to lactic acidosis due to its crucial role as a cofactor for carboxylase enzymes. These enzymes are involved in various metabolic pathways, including the conversion of pyruvate to oxaloacetate in gluconeogenesis and the metabolism of fatty acids and amino acids.

When biotin is deficient, the function of these carboxylases is impaired, particularly that of pyruvate carboxylase. This results in an accumulation of pyruvate, which is then converted to lactate, leading to lactic acidosis. Additionally, biotin deficiency can disrupt the citric acid cycle and gluconeogenesis, further compounding metabolic derangements and resulting in increased levels of lactic acid in the blood.

The other vitamins listed do not have a direct role in the metabolism that leads to lactic acid production or accumulation. For instance, vitamin C is primarily involved in collagen synthesis and antioxidant protection, vitamin E serves as an antioxidant protecting cell membranes, and vitamin D is essential for calcium and phosphate metabolism in the body. Thus, their deficiencies are associated with different clinical scenarios and do not lead to lactic acidosis.