Endometrial polyps may develop as a side effect of which medication?

Endometrial polyps are commonly associated with hormonal influences, and one well-known medication that can contribute to their development is Tamoxifen. Tamoxifen is a selective estrogen receptor modulator (SERM) that is primarily used in the treatment of breast cancer. It works by blocking estrogen receptors in breast tissue while acting as an estrogen agonist in other tissues, such as the endometrium. This agonistic effect on the endometrial tissue can lead to hyperplasia and potentially the formation of endometrial polyps.

Estrogen plays a significant role in the growth and maintenance of the endometrial lining, and any agent that has estrogenic activity, such as Tamoxifen, may predispose to abnormal growths in the endometrium. This side effect necessitates careful monitoring of patients on Tamoxifen for changes in uterine health, including the development of polyps or even endometrial cancer.

Although oral contraceptives and medications like Metformin and Aspirin have their own distinct effects and profiles, they are not notably associated with the promotion of endometrial polyps in the same way. Oral contraceptives often stabilize the endometrial lining and may reduce the risk of such polyps. Metformin, primarily