Excess of which vitamin can lead to toxicity presenting as both liver issues and increased intracranial pressure?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct answer is Vitamin A. Excessive intake of Vitamin A can lead to toxicity characterized by a variety of symptoms, including hepatotoxicity and increased intracranial pressure, commonly known as pseudotumor cerebri.

Vitamin A is a fat-soluble vitamin, and when consumed in excessive amounts—often from high-dose supplements or certain animal sources—it can accumulate in the liver and other tissues, leading to liver dysfunction. Additionally, the increased levels of Vitamin A can result in neurological symptoms due to increased intracranial pressure caused by swelling of the brain and other effects.

While other vitamins mentioned have their own side effects and toxicities, none are typically associated with both liver problems and increased intracranial pressure in the way Vitamin A is. For example, Vitamin D toxicity is often associated with hypercalcemia and renal issues, while Vitamin B12 generally does not have a known toxicity profile leading to these specific symptoms. Vitamin E, although it can have some adverse effects, does not present with issues related to liver toxicity and increased intracranial pressure like Vitamin A does.

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