Haloperidol, similar to chlorpromazine, blocks which receptors?

Haloperidol, as well as chlorpromazine, primarily functions by blocking D2 dopamine receptors. These antipsychotic medications are part of the typical antipsychotics class and are commonly used to treat various psychiatric conditions, including schizophrenia.

The blockade of D2 receptors in the mesolimbic and mesocortical pathways is thought to mediate the antipsychotic effects of these drugs, helping to alleviate symptoms such as hallucinations and delusions. Additionally, the inhibition of D2 receptors plays a crucial role in the side effects associated with antipsychotic therapy, including extrapyramidal symptoms, owing to the disruption of dopaminergic signaling in the nigrostriatal pathway.

In summary, haloperidol and chlorpromazine are effective in treating psychosis due to their action on D2 receptors, making this receptor subtype crucial for their therapeutic activity.