Hepatitis B Virus is an oncogenic DNA virus linked to which cancer type?

Hepatitis B Virus (HBV) is a known oncogenic DNA virus primarily associated with the development of hepatocellular carcinoma (HCC). The link between HBV infection and liver cancer is well established, as chronic infection with HBV can lead to cirrhosis and subsequent malignant transformation of liver cells.

The oncogenic potential of HBV is attributed to several factors, including the integration of viral DNA into the host genome, which can disrupt normal cellular regulatory mechanisms, and the expression of viral proteins, such as the HBV X protein, that can promote oncogenesis by interfering with tumor suppressor genes and enhancing cellular proliferation.

In contrast, the other cancer types listed are not directly associated with HBV. CNS malignant lymphoma is linked to immunosuppression but is more commonly associated with viruses like Epstein-Barr Virus (EBV). Adult T-cell leukemia/lymphoma is associated with Human T-lymphotropic virus (HTLV-1), while small cell carcinoma of the lung has strong associations with smoking and is not linked to HBV infection.