Human T-Lymphotropic Virus 2 (HTLV-2) is known to cause which cancer?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Human T-Lymphotropic Virus 2 (HTLV-2) is primarily associated with hairy cell leukemia, a rare type of leukemia characterized by the accumulation of B cells that appear "hairy" under a microscope. This connection is important as HTLV-2 is one of the retroviruses that can affect immune function and has a known association with certain hematologic malignancies.

While HTLV-1 is well-documented for causing Adult T-cell leukemia/lymphoma, HTLV-2 has a somewhat less-defined relationship but is specifically associated with hairy cell leukemia. Hairy cell leukemia results from neoplastic proliferation of atypical B lymphocytes, and the presence of HTLV-2 may influence the development of this condition.

The other cancers listed do not have a direct correlation with HTLV-2. CNS malignant lymphoma is more often linked to immunosuppression or other factors but not primarily to HTLV-2, and prostate adenocarcinoma has completely different etiological factors unrelated to a viral cause. Therefore, the association of HTLV-2 with hairy cell leukemia makes it the most fitting choice among the options presented.

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