In Cystic Fibrosis, which anatomical structure fails to fully develop in males?

In Cystic Fibrosis, the anatomical structure that fails to fully develop in males is the vas deferens. This condition is part of the male reproductive tract affected by congenital bilateral absence of the vas deferens (CBAVD), which is a common finding in males with Cystic Fibrosis due to mutations in the CFTR gene. The CFTR protein plays a crucial role in the regulation of epithelial ions and fluid transport, and its deficiency can lead to obstruction of the ducts formed during development.

During embryogenesis, the vas deferens develops from the mesonephric ducts, and in individuals with Cystic Fibrosis, the failure of the vas deferens to develop properly can result in infertility. This phenomenon can occur independently of the epididymis, seminal vesicles, or prostate gland, which may still be present even if they are affected by the underlying disease process. Therefore, recognizing the specific impact of the CFTR mutation on the male reproductive tract helps in understanding the broader implications of Cystic Fibrosis.