In Reye's syndrome, which serum level is typically elevated?

In Reye's syndrome, the typical finding is an elevation in serum transaminases, particularly alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Reye's syndrome is a serious condition often associated with viral infections, commonly influenza or varicella (chickenpox), and is particularly seen in children who have taken aspirin during these illnesses.

The elevation of serum transaminases is indicative of hepatic dysfunction, which is a hallmark of Reye's syndrome. This syndrome is characterized by a combination of encephalopathy and liver degeneration, leading to the release of these enzymes into the bloodstream due to hepatocellular injury.

While alterations in other serum markers can occur in various liver pathologies, the specific elevation of serum transaminases helps in diagnosing Reye's syndrome. Recognizing this elevated enzyme level is crucial for differentiating it from other conditions that can present with similar symptoms, such as viral hepatitis.