In the case of warfarin toxicity, what is the acute treatment?

In the scenario of warfarin toxicity, the acute treatment involves the administration of fresh frozen plasma. Warfarin is an anticoagulant that inhibits vitamin K-dependent factors, which include Factors II, VII, IX, and X in the coagulation cascade. In cases of significant bleeding due to warfarin, or when rapid reversal is needed, fresh frozen plasma is preferred because it provides the necessary clotting factors directly and acts quickly to restore hemostatic function.

While vitamin K does play a role in reversing warfarin's effects, particularly for less acute situations or when a more gradual reversal is acceptable, fresh frozen plasma is indicated for immediate provision of factors in acute bleeding situations. This is crucial in emergency settings or when there’s a life-threatening hemorrhage, where repletion of clotting factors needs to occur rapidly.

The other options listed are not appropriate for the acute treatment of warfarin toxicity. Cyclophosphamide is an anticancer drug that bears no relevance to warfarin overdose, while mebendazole is an antiparasitic medication and does not interact with anticoagulation therapy. Thus, the use of fresh frozen plasma is critical for prompt management in such cases.