In which disease is there a classic finding of sensitivity to light and recurrent infections due to defects in phagocyte function?

The classic findings of sensitivity to light and recurrent infections due to defects in phagocyte function are characteristic of Chediak-Higashi disease. This condition is caused by a genetic defect that affects lysosomal trafficking within cells, particularly impacting phagocytes.

In Chediak-Higashi disease, the impaired function of phagocytes leads to an increased susceptibility to infections because neutrophils and other immune cells cannot effectively kill bacteria. Furthermore, individuals with this condition exhibit albinism and photosensitivity, which stems from the abnormal melanin storage in lysosomes. This interplay between immune dysfunction and sensitivity to light supports the diagnosis of Chediak-Higashi disease.

The other conditions listed, while they may involve immune dysfunction or increased susceptibility to certain infections, do not have the combination of light sensitivity and phagocyte dysfunction as a hallmark feature. Chronic granulomatous disease primarily involves a defect in the oxidative burst of phagocytes, Hyper-IgE syndrome is characterized by elevated IgE levels and skin infections, and Wiskott-Aldrich syndrome involves eczema, thrombocytopenia, and immune deficiency, without the light sensitivity that is a defining aspect of Chediak-Higashi disease.