Krabbe's Disease involves the accumulation of what type of lipid?

Krabbe's Disease is a hereditary lysosomal storage disorder caused by a deficiency of the enzyme galactocerebrosidase. This enzyme is responsible for the metabolism of galactocerebrosides, which are a type of lipid found in the myelin sheath of nerve cells. When galactocerebrosidase is deficient, galactocerebrosides accumulate, leading to the demyelination of neurons and the neurological symptoms associated with Krabbe's Disease.

The accumulation results in severe neurological dysfunction, including the disruption of myelin formation and maintenance. This is central to understanding the pathology of Krabbe's Disease, as the clinical manifestations stem from this demyelination process. The other lipid types listed in the options pertain to different lysosomal storage disorders and do not relate to Krabbe's Disease. Therefore, the correct identification of the lipid type involved in Krabbe's Disease is crucial for understanding both the biochemical pathophysiology of the condition and its clinical implications.