Losartan is primarily known for blocking which type of receptors?

Losartan is primarily known for its action as an antagonist of angiotensin II receptors. It specifically targets the AT1 subtype of the angiotensin II receptor, which plays a critical role in regulating blood pressure and fluid balance. By blocking these receptors, Losartan helps to decrease vasoconstriction and reduce the secretion of aldosterone, leading to lower blood pressure. This mechanism is particularly beneficial in the management of conditions such as hypertension and heart failure, where decreased receptor activation can improve vascular resistance and cardiac performance.

This understanding highlights the importance of angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and how its blockade can lead to therapeutic effects in cardiovascular health.