Obesity leads to a decrease in which type of receptors?

Obesity significantly impacts metabolic pathways and the functioning of various receptors in the body. In particular, obesity is associated with a decrease in insulin receptors and insulin sensitivity.

In a state of obesity, there is often an increase in circulating free fatty acids and inflammatory cytokines, which contribute to insulin resistance. This means that even though insulin is being produced, the body's tissues (such as muscle and adipose tissue) become less responsive to insulin due to the downregulation or dysfunction of insulin receptors. As a result, glucose uptake is impaired, leading to increased blood glucose levels and, over time, may contribute to the development of type 2 diabetes.

The focus on insulin receptor decrease specifically highlights how obesity alters insulin signaling pathways, making the body less effective at using glucose for energy. The relationship between obesity and insulin resistance is well-documented and is a key concern in managing obesity-related health issues.