Skeletal manifestations in patients with anorexia nervosa may include which condition?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

In patients with anorexia nervosa, one significant skeletal manifestation is osteoporosis. This condition is characterized by a reduction in bone mass and deterioration of bone tissue, leading to increased fragility and a higher risk of fractures.

The development of osteoporosis in individuals with anorexia nervosa is primarily attributed to several factors associated with the disorder. These include malnutrition, which results in inadequate intake of essential nutrients necessary for bone health, such as calcium and vitamin D. Furthermore, the hormonal changes that accompany anorexia, including decreased estrogen levels in females, can contribute to accelerated bone loss. The combination of low body weight, reduced physical activity, and hormonal imbalances creates an environment conducive to decreased bone density and increased susceptibility to osteoporosis.

Osteoporosis is a particularly concerning complication because it may persist even after weight restoration and treatment of the eating disorder, making it an essential aspect of care and monitoring in these patients. Regular bone density assessments and discussing strategies to improve bone health become critical components of the management plan for individuals recovering from anorexia nervosa.

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