Vitamin K excess leads to which of the following conditions?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Vitamin K plays a crucial role in the synthesis of certain coagulation factors, specifically factors II (prothrombin), VII, IX, and X, as well as proteins C and S. These proteins are essential for the normal clotting process. An excess of vitamin K does not typically lead to a decrease in the synthesis of these factors; instead, it can enhance their production, leading to an increased coagulable state.

While the other conditions listed—such as jaundice, hypercalcemia, and increased arterial stiffness—can be associated with various medical conditions, they are not directly caused by vitamin K excess. In fact, jaundice in newborns is often related to vitamin K deficiency rather than excess, as newborns can have an immature liver function leading to poor processing of vitamin K. Likewise, hypercalcemia and increased arterial stiffness are unrelated to vitamin K metabolism. Therefore, the assertion that vitamin K excess leads to decreased synthesis of coagulation factors is not accurate, as the factors are instead synthesized more effectively in the presence of adequate levels of the vitamin.

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