What are Sezary cells characteristic of in pathology?

Sezary cells are indeed characteristic of mycosis fungoides, a type of cutaneous T-cell lymphoma. These atypical lymphocytes are known for their distinctive morphology, which includes convoluted or lobulated nuclei. They are typically found in the blood and represent the leukemic form of cutaneous T-cell lymphoma, where malignant T-cells spread from the skin to the bloodstream.

In mycosis fungoides, Sezary cells can be present alongside other signs of skin involvement, such as patches or plaques on the skin. Their presence in peripheral blood indicates a more advanced stage of the disease and can have implications for prognosis and treatment strategies.

The other options present different concepts unrelated to Sezary cells. For instance, neoplastic aggregates in the epidermis are more closely associated with the manifestation of the disease rather than Sezary cells themselves. Increased basophils in chronic myeloid leukemia and the JAK2 mutation pertain to different hematological disorders and do not relate to the pathology associated with Sezary cells. Therefore, recognizing Sezary cells as specifically indicative of mycosis fungoides is essential in understanding their role in pathology.