What change in pH is associated with a right shift in the oxygen dissociation curve?

A right shift in the oxygen dissociation curve indicates a decrease in the affinity of hemoglobin for oxygen, which facilitates oxygen release to the tissues. This physiological response is primarily influenced by various factors, one of which is pH.

When the pH decreases, a condition known as acidosis occurs. This decrease in pH is typically associated with increased concentrations of carbon dioxide (CO2) or an increase in lactic acid, both of which enhance the release of oxygen from hemoglobin. This phenomenon is described by the Bohr effect, where increased levels of CO2 and hydrogen ions (H+) lead to hemoglobin's decreased affinity for oxygen.

Thus, a decrease in pH results in a right shift of the oxygen dissociation curve, allowing more oxygen to be released in tissues that are in need of it, such as actively metabolizing tissues producing more CO2 and H+.