What common complication can arise in advanced cervical carcinoma leading to mortality?

Advanced cervical carcinoma can lead to several complications, one of which is significant urinary tract obstruction due to local tumor invasion. As the tumor grows, it can encroach upon the ureters, leading to ureteral obstruction. This obstruction can prevent urine from flowing from the kidneys to the bladder, resulting in the urine backing up into the kidneys.

When urine builds up in the kidneys as a consequence of this obstruction, it can lead to hydronephrosis, which is the swelling of a kidney due to the accumulation of urine. Over time, this condition can result in renal parenchymal damage and subsequently lead to postrenal acute kidney injury or renal failure. This progression can severely impair kidney function and may ultimately lead to life-threatening complications such as uremia, electrolyte imbalances, or the need for renal replacement therapy.

In advanced cervical cancer, especially in cases where the disease has spread or invaded surrounding structures, the risk of these complications increases significantly and can ultimately contribute to the patient's mortality. This makes hydronephrosis with postrenal failure a critical and common complication in advanced cases of cervical carcinoma.