What condition is characterized by an inability to hydrolyze chylomicrons and a deficiency in ApoC-II?

Familial lipoprotein lipase deficiency is characterized specifically by a deficiency in lipoprotein lipase, an enzyme crucial for the hydrolysis of chylomicrons and triglycerides. This condition leads to an accumulation of triglyceride-rich lipoproteins in the plasma, resulting in severe hypertriglyceridemia. ApoC-II is an essential cofactor for lipoprotein lipase; without it, the enzyme cannot function properly, contributing to the inability to hydrolyze chylomicrons efficiently.

Patients typically present with symptoms such as abdominal pain, pancreatitis, and eruptive xanthomas due to the elevated triglyceride levels. The absence of ApoC-II impairs lipoprotein lipase activity, highlighting the direct relationship between ApoC-II deficiency and the inability to hydrolyze chylomicrons effectively, making this condition distinct among other lipid disorders listed.

Familial hypertriglyceridemia is more a general term for elevated triglycerides and does not specifically indicate a deficiency in ApoC-II or the inability to hydrolyze chylomicrons. Abetalipoproteinemia involves a deficiency in the protein required for the assembly of chylomicrons, leading to a different clinical picture, including malabs