What condition is indicated by bilateral hilar adenopathy and uveitis?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Bilateral hilar adenopathy and uveitis are hallmark findings in sarcoidosis. This systemic granulomatous disease is characterized by the accumulation of immune cells, leading to the formation of granulomas in various tissues, most commonly affecting the lungs and lymphatic system.

In sarcoidosis, uveitis—an inflammation of the uvea (the middle layer of the eye)—often occurs and is viewed as a significant extra-pulmonary manifestation. The bilateral hilar adenopathy refers to the enlarged lymph nodes located at the root of the lungs, which is typically identified on imaging studies such as chest X-rays or CT scans.

While other conditions, such as tuberculosis, lymphoma, and granulomatosis with polyangiitis, can also present with various pulmonary findings, they typically do not combine bilateral hilar adenopathy and uveitis in the same consistent manner as sarcoidosis does. For instance, tuberculosis may cause similar lung findings but typically presents with more systemic symptoms such as fever, night sweats, and weight loss, and usually does not feature uveitis. Lymphoma can present with hilar adenopathy but is less commonly associated with uveitis. Granulomatosis with polyangiitis often presents with renal involvement and

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