What conditions are known to show a rash on palms and soles?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct answer identifies Coxsackie A virus infections and Rocky Mountain spotted fever as conditions that can present with a rash on the palms and soles.

Coxsackie A virus is notorious for causing hand, foot, and mouth disease, which typically results in vesicular lesions primarily on the palms and soles, alongside oral lesions. This presentation is particularly important in younger populations and is easily recognizable due to its distribution.

Rocky Mountain spotted fever, caused by Rickettsia rickettsii, also shows a characteristic rash that can involve the palms and soles. Early involvement of these areas is clinically significant, often occurring after a period of fever and general malaise. The rash evolves from a macular to a petechial appearance and can be life-threatening if not treated promptly.

Other options, while they may involve rashes, do not typically include the palms and soles as part of their common presentations. Psoriasis and eczema tend to affect other areas of the body more prominently, while Henoch-Schönlein purpura usually presents with purpura rather than a classic rash involving these specific regions. Contact dermatitis and tinea corporis also present with rashes, but these conditions do not commonly affect the palms and soles in the same

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