What deficiency can result in hemolytic anemia and peripheral neuropathy?

A deficiency in vitamin E can lead to hemolytic anemia and peripheral neuropathy due to its role as an antioxidant in the body. Vitamin E protects cell membranes from oxidative damage caused by free radicals. In its absence, red blood cells can undergo oxidative stress, leading to hemolysis, which is the premature destruction of red blood cells. This results in hemolytic anemia, characterized by symptoms such as fatigue and pallor.

Additionally, vitamin E is crucial for maintaining the integrity of neuronal membranes. When a deficiency occurs, it can affect the peripheral nervous system, leading to neuropathy characterized by symptoms like weakness, numbness, or tingling in the extremities. These manifestations highlight how integral vitamin E is for not only blood cell health but also for proper nerve function.

Other vitamins listed do not directly link to both hemolytic anemia and peripheral neuropathy in the same way. For example, vitamin A is primarily associated with vision and immune function, vitamin K is essential for blood clotting, and vitamin C is important for collagen synthesis and antioxidant protection but does not specifically lead to these combinations of hematologic and neurologic issues.