What deficiency is associated with dermatitis, alopecia, glossitis, and lactic acidosis?

The deficiency associated with dermatitis, alopecia, glossitis, and lactic acidosis is biotin deficiency. Biotin, also known as vitamin B7, plays a crucial role as a coenzyme in various carboxylation reactions that are essential for the metabolism of carbohydrates, fats, and proteins.

Dermatitis is often observed in biotin deficiency, typically presenting as a scaly rash predominantly on the face and around the eyes. Alopecia, or hair loss, is another common symptom due to biotin's role in maintaining healthy hair follicles. Glossitis, which refers to inflammation of the tongue, can occur as well, leading to a swollen, painful tongue that may affect oral health and comfort.

Lactic acidosis can develop in the context of biotin deficiency because impaired metabolism may lead to an accumulation of lactate, especially in situations where glycolysis is affected, and the body cannot effectively convert pyruvate into acetyl-CoA.

The other options do not align with this combination of symptoms. For instance, vitamin A deficiency primarily leads to visual disturbances and skin issues, vitamin D deficiency is associated with bone problems such as rickets or osteomalacia, and vitamin E deficiency is known for neurological deficits and hemolytic anemia