What deficiency is caused by Hartnup's disease?

Hartnup's disease is a genetic disorder characterized by the impaired absorption of certain amino acids, particularly tryptophan, in the kidneys and intestinal tract. Tryptophan is crucial for the synthesis of niacin (vitamin B3) through the metabolic pathway that converts it into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), both of which are essential coenzymes in various metabolic processes.

Due to the significant loss of tryptophan in Hartnup's disease, individuals may develop a deficiency in niacin. This can lead to symptoms associated with niacin deficiency, such as pellagra, which is characterized by dermatitis, diarrhea, and dementia. The relationship between tryptophan and niacin underlines the importance of adequate amino acid absorption for maintaining proper vitamin levels in the body.

While riboflavin (B2), pyridoxine (B6), and vitamin C deficiencies can cause their own distinct health issues, they are not the direct result of the absorption problems seen in Hartnup's disease. The primary focus in this condition is on the defective transport of specific amino acids leading to niacin deficiency due to reduced try