What disease is characterized by recurrent inflammation and thrombosis of small and medium vessels in the extremities?

Buerger's disease, also known as thromboangiitis obliterans, is characterized by recurrent inflammation and thrombosis of small and medium-sized blood vessels, particularly in the extremities. This condition predominantly affects the arteries and veins in the arms and legs, leading to complications such as pain, ulceration, and potentially gangrene due to reduced blood flow.

The hallmark of Buerger's disease is a strong association with smoking; it primarily affects young male smokers. The inflammation and occlusion of blood vessels by thrombi can result in significant ischemic symptoms, particularly during physical activity or exposure to cold temperatures, which is often confused with symptoms seen in Raynaud's disease.

This disease has unique immunological aspects and pathophysiology, with evidence of vasculitis contributing to vascular occlusion. Diagnosis is often made based on clinical features, as well as excluding other causes of vascular disease.

The other conditions listed, while related to vascular issues, do not have the same specific pattern of recurrent inflammation and thrombosis associated primarily with Buerger's disease. Raynaud's disease primarily involves vasospastic episodes rather than inflammation and thrombosis, peripheral artery disease is more commonly associated with atherosclerosis rather than the inflammatory nature