What histological structure is associated with a Yolk sac tumor?

The presence of Schiller-Duval bodies is a defining histological feature of a yolk sac tumor, also known as an endodermal sinus tumor. These structures resemble glomeruli and are composed of a core of connective tissue surrounded by germ cells, which can include various mixtures of the germ cell types found in these tumors. Yolk sac tumors are part of the germ cell tumor classification and are known to produce alpha-fetoprotein (AFP), a marker that can aid in diagnosis.

Schiller-Duval bodies are important diagnostic indicators when histologically assessing specimens for yolk sac tumors, helping distinguish them from other types of germ cell tumors, which may exhibit very different histological characteristics, such as keratin pearls in squamous cell carcinoma or giant cells in certain types of sarcomas. Thus, identifying Schiller-Duval bodies is crucial in confirming the diagnosis of a yolk sac tumor and guiding appropriate treatment strategies.