What is a characteristic feature of thyroid hormone deficiency in neonates?

A characteristic feature of thyroid hormone deficiency in neonates, often referred to as congenital hypothyroidism, is an enlarged tongue, known as macroglossia. This condition arises because thyroid hormones are crucial for normal development and growth, particularly of the body's tissues and organs.

In neonates with this deficiency, one can observe various physical manifestations due to a lack of hormones necessary for metabolism and growth. An enlarged tongue can interfere with feeding and may indicate the systemic effects of insufficient thyroid hormone.

Other signs of thyroid hormone deficiency in newborns may include other physical features like hypotonia (decreased muscle tone), dry skin, and poor weight gain, but macroglossia is a distinctive feature often noted clinically. The presence of this symptom can be important for timely diagnosis and management, as early intervention is critical to prevent developmental delays associated with untreated congenital hypothyroidism.