What is a common age-related change in the musculoskeletal system?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct answer highlights osteoporosis as a common age-related change in the musculoskeletal system. Osteoporosis is characterized by a decrease in bone density and strength, leading to increased fragility and a higher risk of fractures. As individuals age, the balance between bone resorption and bone formation becomes disrupted, contributing to a reduction in bone mass, particularly after menopause in women due to decreased estrogen levels, which play a crucial role in maintaining bone density.

Other age-related changes in the musculoskeletal system may occur, but they do not encompass the widespread and significant impact of osteoporosis. While Paget's disease can affect older adults, it is not universally common and is generally localized rather than widespread. Increased joint stability is not characteristic of age; rather, aging often leads to decreased stability due to factors such as joint degeneration and muscle atrophy. Muscle hypertrophy typically occurs as a response to resistance training, but with age, individuals often experience muscle atrophy rather than hypertrophy. Therefore, osteoporosis stands out as the most prevalent and clinically relevant condition associated with aging in the musculoskeletal system.

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