What is a common cause of hypoparathyroidism?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

Hypoparathyroidism is most commonly caused by inadvertent damage to or excision of the parathyroid glands, often occurring during thyroid surgery. The parathyroid glands are located very close to the thyroid gland, making them susceptible to injury during procedures such as thyroidectomy. When these glands are removed or damaged, the production of parathyroid hormone (PTH), which regulates calcium levels in the blood, is impaired. This can lead to symptoms associated with hypocalcemia, such as muscle cramps, tetany, and convulsions.

The other options listed do not directly cause hypoparathyroidism. While a pituitary adenoma can affect hormone levels, it primarily influences pituitary hormones and is not a common cause of parathyroid dysfunction. Alcoholic cirrhosis primarily affects liver function and can have numerous systemic effects, but it does not directly involve the parathyroid glands. Prostatic carcinoma primarily presents with its own distinct issues and does not typically lead to hypoparathyroidism. Therefore, the scenario of accidental excision during thyroidectomy is the most straightforward and common cause leading to this condition.

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