What is a common complication of cystic fibrosis related to lung health?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

A common complication of cystic fibrosis that relates to lung health is the presence of mucous plugs. Cystic fibrosis leads to a mutation in the CFTR gene, which affects the transport of chloride ions and results in the production of thick, viscous mucus. This thick mucus can obstruct the airways, leading to the formation of mucous plugs.

These plugs can cause significant problems in respiratory function, as they block airflow and create an environment conducive to infection. As a result, areas of the lung become isolated and unable to effectively clear mucus, resulting in further complications. Over time, the obstruction from these plugs can also contribute to inflammation and damage to lung tissue.

While other options like bronchiectasis, pulmonary hypertension, and recurrent pneumonia are also complications associated with cystic fibrosis, they typically arise as a result of the chronic obstruction and infection from the mucous plugs. Thus, the formation of mucous plugs is a primary and common complication that directly affects lung health in individuals with cystic fibrosis.

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