What is a key histological feature of a Leiomyosarcoma?

A key histological feature of a leiomyosarcoma is the presence of areas of necrosis and hemorrhage. Leiomyosarcoma, which is a malignant tumor derived from smooth muscle, often exhibits aggressive behavior and can show extensive areas of necrosis due to rapid tumor growth that outpaces its blood supply. These necrotic regions are indicative of the tumor's aggressive nature and can be a crucial diagnostic criterion when evaluating histological samples.

Additionally, while high mitotic index can also be observed in leiomyosarcoma, the presence of necrosis and hemorrhage is a more definitive feature, as it directly reflects the tumor's malignancy and growth characteristics. In contrast, keratin pearls are typically associated with squamous cell carcinoma and psammoma bodies with certain types of tumors like papillary serous carcinoma.