What is a significant complication associated with Paroxysmal Nocturnal Hemoglobinuria?

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired hematological disorder characterized by the destruction of red blood cells, leading to hemolytic anemia. One of the significant complications of PNH is indeed iron deficiency anemia. This occurs because the hemolysis associated with PNH leads to the release of hemoglobin into the plasma, which is subsequently lost in the urine. The breakdown of hemoglobin results in decreased iron stores, as the body loses iron that would otherwise be recycled from the hemoglobin.

Over time, as hemolysis continues, the body's iron levels become depleted, potentially leading to symptoms of anemia, such as fatigue and pallor. Patients may require iron supplementation to manage this complication effectively. Hence, it is crucial to monitor iron levels and manage any deficiencies proactively in individuals diagnosed with PNH, as chronic hemolysis is a predominant feature of the disease.

The other options, while they may pertain to various hematological conditions, are not direct complications associated with PNH. Iron deficiency anemia arises specifically from the chronic hemolytic process inherent to the disorder, making it a significant and relevant complication to consider in the context of PNH.