What is the classic triad of symptoms in Pellagra?

Pellagra is a condition caused by a deficiency of niacin (Vitamin B3) and is characterized by a classic triad of symptoms: dermatitis, dementia, and diarrhea. Each of these symptoms is associated with the underlying biochemical changes that occur due to the lack of niacin in the body.

Dermatitis typically presents as a rash in areas of the body exposed to sunlight, often referred to as photosensitive dermatitis. The skin lesions can become crusted, hyperpigmented, and scaly.

Dementia in the context of Pellagra can manifest as cognitive decline, confusion, and other neurological symptoms. This occurs due to the role niacin plays in the synthesis of important neuropeptides and cellular metabolism in the brain.

Diarrhea results from the effects of niacin deficiency on the gastrointestinal tract, leading to inflammation and impaired absorption.

This triad of symptoms is distinct and indicative of Pellagra, thus helping healthcare professionals identify the condition effectively. The other options listed describe symptoms associated with various other conditions but do not relate to Pellagra, making them incorrect in this context.