What is the histological presentation of giant B cells in Hodgkin's lymphoma?

The histological presentation of giant B cells in Hodgkin's lymphoma is characterized by bilobed nuclei with prominent inclusions. These giant cells, known as Reed-Sternberg cells, are a hallmark feature of Hodgkin's lymphoma. The classic appearance of these cells involves two large nuclei that resemble "owl eyes," often accompanied by abundant cytoplasm.

These distinctive characteristics aid in the diagnosis of Hodgkin’s lymphoma, as the presence of Reed-Sternberg cells is a critical factor in differentiating this type of lymphoma from other forms of lymphoproliferative disorders. Their unique morphology, particularly the bilobed structure of the nuclei, helps pathologists confirm the diagnosis during microscopic evaluation of biopsy specimens.

The other options do not represent the histological features associated with giant B cells in Hodgkin's lymphoma. Ground-glass nuclei and koilocytic changes are associated with other types of cellular pathology, such as viral infections, while Councilman bodies are indicative of viral hepatitis, appearing in the context of hepatocyte degeneration.