What is the likelihood of males with Cystic Fibrosis having biological children?

Males with cystic fibrosis (CF) often have a condition known as congenital absence of the vas deferens (CAVD), which leads to the obstruction and absence of the duct that carries sperm from the testes. This anatomical abnormality often results in significant infertility for these individuals, as the sperm can't reach the urethra for ejaculation.

Studies indicate that while some men with cystic fibrosis may have a small number of viable sperm in their testes, the majority will face challenges that severely limit reproductive potential. The availability of assisted reproductive technologies, such as sperm retrieval techniques, can allow some men to father children, but the natural likelihood of producing biological children is still significantly reduced due to the underlying mechanisms of their condition.

Thus, the overall conception rate for biological children among men with cystic fibrosis is generally regarded to be less than 5%. This figure reflects the challenges posed by the condition, including reproductive tract anomalies and the need for assisted reproductive technologies.