What is the main reason collagen's tensile strength is weakened in scurvy?

In scurvy, the primary issue is related to the lack of cross-linking in collagen fibers due to a deficiency of vitamin C (ascorbic acid). Vitamin C is essential for the hydroxylation of proline and lysine residues in collagen, which is a crucial step in collagen stability and structure. This hydroxylation process facilitates the formation of cross-links between collagen molecules, which significantly contribute to collagen's tensile strength.

Without sufficient vitamin C, these cross-links cannot form adequately, leading to weakened collagen fibers. As a result, the structural integrity of connective tissues that rely on collagen is compromised. This weakening manifests in various symptoms of scurvy, such as easy bruising, joint pain, and delayed wound healing. The absence of properly formed cross-bridges means that the collagen fibers are less stable and capable of withstanding tensile stress, ultimately leading to the characteristic features of scurvy.

The other options do not accurately capture the primary defect in scurvy as it relates to collagen. Lack of amino acids pertains to nutritional deficits but is not the core issue in scurvy. Excessive collagen breakdown is not a direct consequence of scurvy; instead, the problem lies in collagen formation and stability. Vitamin D deficiency