What is the most abundant glycosaminoglycan (GAG) that serves as a component of cartilage?

Chondroitin sulfate is the most abundant glycosaminoglycan found in cartilage, making it a crucial component of the extracellular matrix in this tissue. It plays a significant role in providing structural support and resilience to cartilage, contributing to its ability to withstand compressive forces. Chondroitin sulfate binds to proteins, forming proteoglycans that interact with collagen fibers in cartilage, which is essential for cartilage's mechanical properties and overall function.

While hyaluronic acid is also present in cartilage and contributes to its hydration and viscosity, it is less abundant in the specific context of cartilage than chondroitin sulfate. Heparan sulfate and keratan sulfate are glycosaminoglycans found in various tissues, but they are not the primary components of cartilage, thus making chondroitin sulfate the standout choice in this context.