What is the most common type of monoclonal protein in multiple myeloma?

In multiple myeloma, the most common type of monoclonal protein produced is indeed IgG. This condition is characterized by the proliferation of a single clone of plasma cells, which leads to the excessive production of immunoglobulins. Among the various immunoglobulin classes, IgG is the most frequently produced protein in patients with multiple myeloma, accounting for approximately 60-70% of cases.

The predominance of IgG is significant as it can be identified in serum or urine, often confirmed by electrophoresis. Understanding this is crucial for diagnosing and monitoring the disease. While IgA, IgM, and IgD can also arise in multiple myeloma, they are considerably less common than IgG, making IgG the hallmark immunoglobulin in this hematological malignancy.