What is the name of the formation characterized by stacks of red blood cells?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct choice is the term for the phenomenon where red blood cells aggregate and form stacks, resembling a stack of coins. This is known as "rouleaux formation." This formation occurs due to changes in the plasma protein composition, particularly an increase in certain proteins like fibrinogen or immunoglobulins which enhances the interactions between red blood cells.

In certain pathological conditions, such as multiple myeloma or chronic inflammatory states, the increased levels of these proteins lead to this stacking effect, which can be observed under a microscope. Rouleaux formation can be seen in specific laboratory tests and can be indicative of underlying disease processes that affect plasma protein levels.

In contrast, the other options listed pertain to types of anemia characterized by the size and morphology of red blood cells rather than the aggregation of red blood cells. Microcytic anemia refers to anemia where red blood cells are smaller than normal, often associated with iron deficiency. Normocytic anemia describes a condition where red blood cells are of normal size but are fewer in number, which can result from various causes, such as chronic disease or acute blood loss. Macrocytic anemia, on the other hand, is marked by larger than normal red blood cells, typically associated with vitamin B12 or fol

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