What is the primary consequence of collagen synthesis inhibition in scurvy?

In scurvy, caused by a deficiency of vitamin C, the primary consequence of collagen synthesis inhibition is the weakening of collagen structure. Vitamin C is essential for the hydroxylation of proline and lysine residues in collagen, which is crucial for forming stable collagen triple helices. Without sufficient vitamin C, collagen fibers become unstable and poorly formed.

This instability leads to a variety of symptoms associated with scurvy, such as easy bruising, fragile blood vessels, and poor wound healing, as the physical properties and strength of collagen are compromised. Consequently, affected individuals may experience joint pain, bleeding gums, and even systemic issues due to the overall weakening of connective tissues throughout the body.

While the other options might seem plausible, they do not represent the primary effect of impaired collagen synthesis in scurvy. Improved wound healing and enhanced vascular strength are contrary to the pathological consequences of inadequate collagen, while redundant collagen formation does not occur, as the overall collagen synthesis is severely hampered. Therefore, the essence of scurvy lies in the weakening of collagen structure due to the lack of necessary vitamin C, which is critical for maintaining the integrity of collagen in the body.