What is the recommended acute treatment for a gout attack?

In the management of an acute gout attack, nonsteroidal anti-inflammatory drugs (NSAIDs) are typically the first-line treatment option. During an acute attack of gout, the primary goal is to reduce inflammation and alleviate pain. NSAIDs are effective in achieving these results due to their ability to inhibit the cyclooxygenase enzymes (COX-1 and COX-2), which play a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins that promote inflammation, pain, and fever.

Commonly used NSAIDs for treating an acute gout attack include indomethacin and naproxen. These medications are favored because they can provide rapid relief of symptoms, are generally well-tolerated, and have a good safety profile when used appropriately.

Corticosteroids and colchicine are alternative treatments when NSAIDs are contraindicated or not tolerated. Corticosteroids can effectively reduce inflammation, but they are often reserved for cases where NSAIDs are not suitable, such as in patients with renal issues or other contraindications. Colchicine is also effective in managing gout attacks, particularly if administered early in the course of the attack, but it can have side effects related to gastrointestinal distress and may not be as