What is the recommended antibiotic therapy for MRSA infections?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The recommended antibiotic therapy for MRSA (Methicillin-resistant Staphylococcus aureus) infections is vancomycin. Vancomycin is a glycopeptide antibiotic that is effective against Gram-positive bacteria, including MRSA. The mechanism of action involves inhibiting bacterial cell wall synthesis, which is crucial for the bacteria's viability and proliferation. Given the resistance of MRSA to beta-lactam antibiotics, which include methicillin and other common penicillins, vancomycin has emerged as the first-line treatment in severe MRSA infections.

While clindamycin and trimethoprim-sulfamethoxazole are also effective against MRSA and are alternatives in certain cases, vancomycin is preferred for serious infections due to its broad coverage and established efficacy. Ciprofloxacin, on the other hand, is primarily effective against Gram-negative bacteria and is not suitable for treating MRSA infections, making it an inappropriate choice.

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