What is the viral cause of slapped cheeks rash in children?

The viral cause of slapped cheeks rash in children is Parvovirus B19. This virus is known to cause "fifth disease" or erythema infectiosum, which typically presents with a distinctive rash characterized by bright red cheeks that resemble being slapped, followed by a lacy, reticular rash that can spread to the body and limbs. Parvovirus B19 primarily affects children but can also cause mild illness in adults.

The infection often starts with mild symptoms such as fever, headache, and malaise before the classic rash appears. Importantly, Parvovirus B19 is also known for its ability to cause aplastic anemia in individuals who have underlying hemolytic anemia due to its impact on erythroid progenitor cells in the bone marrow.

Other viruses such as Rubella, Measles, and Herpes simplex virus are associated with different clinical presentations and do not typically cause the characteristic slapped cheek appearance. Rubella virus causes a rash that starts on the face and spreads downward but does not have the same presentation as Parvovirus B19. Measles virus is associated with a more generalized rash and other systemic symptoms, and Herpes simplex virus is primarily associated with vesicular lesions. Thus, Parvovirus B