What organism is NOT typically involved in infections in chronic granulomatous disease?

In chronic granulomatous disease (CGD), patients have a defect in the NADPH oxidase enzyme complex, which leads to impaired production of reactive oxygen species (ROS) and deficient phagocyte killing of certain types of bacteria and fungi. As a result, individuals with CGD are particularly susceptible to infections caused by catalase-positive organisms, as these pathogens can neutralize the hydrogen peroxide produced by the host as a defense mechanism.

Aspergillus species and Staphylococcus aureus are both catalase-positive organisms and are common pathogens associated with infections in patients with CGD. E. coli, being a catalase-negative organism, is typically not a common pathogen in CGD patients, but it is not as closely associated with susceptibility as the previously mentioned organisms.

In contrast, Streptococcus pyogenes, which is a catalase-negative organism, does not have the same enzymatic defense mechanisms as catalase-positive organisms and is not particularly associated with CGD-related infections. Patients with CGD are less prone to infections by organisms like Streptococcus pyogenes because their immune system can still effectively manage these types of encapsulated and catalase-negative bacteria. Therefore, Streptococcus pyogenes is the organism that is not typically involved