What substance, when increased, results in a turbid supranate in serum?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The presence of chylomicrons in the serum is responsible for producing a turbid, or cloudy, supranate. Chylomicrons are large lipoprotein particles that transport dietary lipids from the intestines to other locations in the body, including the liver and peripheral tissues. When their concentration in the serum increases, particularly after a high-fat meal, they can give the plasma a milky appearance due to the high lipid content.

In contrast, while VLDL, LDL, and HDL are also types of lipoproteins that play essential roles in lipid metabolism and transport, they are generally smaller and their presence does not induce the same degree of turbidity in serum as chylomicrons. VLDL can also contribute to a cloudy appearance, but typically not to the same extent as chylomicrons post-prandially. Therefore, an increase in chylomicron levels is the primary cause of a turbid supranate in serum, making it the correct answer.

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