What type of inheritance does Chronic Granulomatous disease display?

Chronic Granulomatous Disease (CGD) primarily results from defects in the NADPH oxidase complex, which affects the ability of phagocytes—specifically neutrophils—to produce reactive oxygen species necessary for killing certain types of bacteria and fungi. The most common form of CGD follows an X-linked recessive inheritance pattern, predominantly affecting males. However, there are also autosomal recessive forms associated with mutations in other subunits of the NADPH oxidase complex.

In the context of your selected answer, implying autosomal recessive inheritance could refer to the fact that while many cases (especially X-linked) are seen in males, there are also genetic mutations that lead to CGD via an autosomal recessive mechanism. In families or individuals where both parents are carriers of an autosomal recessive gene, offspring could indeed inherit CGD through this mechanism.

As such, the identification of hereditary patterns is nuanced and can differ based on the specific genetic mutation involved in the pathogenesis of CGD. The X-linked recessive inheritance is more commonly recognized, but the presence of autosomal recessive cases expands the understanding of the disease's genetic diversity. Therefore, the notion of autosomal recessive inheritance captures an important aspect of CGD