What type of inheritance pattern is associated with diseases that primarily affect males and are passed from mother to son?

Prepare for USMLE Step 1 Pathology Exam with comprehensive quizzes, flashcards, and detailed explanations. Enhance your understanding and be exam-ready!

The correct response highlights the concept of X-linked recessive inheritance, which is characterized by traits or diseases that predominantly affect males while being transmitted from mother to son. In X-linked recessive disorders, the gene responsible for the condition is located on the X chromosome. Males, having only one X chromosome (XY), will express the disease if they inherit an affected X chromosome from their mother, who may be a carrier or affected herself with the condition.

Because females have two X chromosomes (XX), they can be carriers (having one affected X chromosome and one normal X chromosome) without expressing the disease, provided they have one normal X chromosome to compensate. Therefore, if a mother is a carrier of an X-linked recessive disorder, there is a 50% chance that each son will inherit the affected X chromosome and express the disease, while daughters have a 50% chance of being carriers.

In contrast, the other inheritance patterns do not reflect the specific characteristics of the question. Autosomal dominant disorders affect both males and females equally and can be passed from an affected parent to offspring regardless of sex. Y-linked inheritance affects only males, as the Y chromosome is only inherited by male offspring, and it typically does not manifest in females. Autosomal

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